Nowell replaces the injured Chris Ashton on the wing while Moon steps in for the sidelined Mako Vunipola at loose-head prop. He recently made his first start for England in the Six Nations since 2013 during the second round clash against France.
Cokanasiga scored on his return from injury for Bath last weekend, while Shields is selected ahead of Nathan Hughes as forward cover.
"You grow up watching that match, respecting the great players and victories down the years and want to have a part in it".
"There is more in us, and hopefully we can do that".
"Full credit to Wales, they played very well and deserved to win today". "We know the areas we can be better in and we will learn from this".
But Wales are also protecting an unbeaten record. They trailed France 16-0 before fighting back to win, while a much-changed team laboured to victory over Italy in Rome.
'We just didn't get a foothold in the last 30 mintues of the game if were honest, ' Farrell said after the game.
"The effect it has on the country if we win is unbelievable".
Chasing an elusive Grand Slam, England knew a positive result would deliver a first clean sweep for a decade, while a defeat by six points or less would still seal the championship. "I don't think England created anything really; they didn't put us under any pressure".
Wales Starting XV: 15. He'll be marked by George North, who is bigger but not faster.
Wales had only conceded two penalties, but Curry forced Hadleigh Parkes to hold on moments later. Anscombe has a massive task on his hands to match Farrell from the tee having been preferred to Dan Biggar and with regular kicker Leigh Halfpenny out of action. Openside flanker - Justin Tipuric v Tom Curry: England's breakdown problems have dogged them since Stuart Lancaster's reign but they finally appear to be solved with the emergence of Curry and his rival for the No 7 shirt Sam Underhill. Alun Wyn Jones (captain), 4.
Wales - Tries: Cory Hill, Josh Adams. Nicky Smith, 18. Dillon Lewis, 19.
Indeed, only twice this century have the two teams exceeded that total on Welsh soil - 2007, when England needed a large winning margin to have a chance of lifting the trophy but were beaten 27-19, and a 44-15 England win in 2001.
With the Principality Stadium's retractable roof open at England's request, the visitors saw long-range kick specialist Elliot Daly push an early 48-metre effort wide of the left post.
They had been working, Gatland explained, on closing down Farrell and Ben Youngs, cutting short the time they had to work in.
But from one such kick, England lock George Kruis stole possession off a Welsh throw-in.
Biggar's first act as a replacement for Anscombe was to land a conversion four metres in from the touchline to send Wales into a 16-13 lead.