An open seat that included Atlantic City was also ripe for Democratic pickup by state lawmaker Jeff Van Drew after the GOP campaign committee abandoned Republican Seth Grossman over racially charged comments.
Yet Trump's party will maintain Senate control for the next two years, at least. The Florida Senate race between Democrat Bill Nelson and Republican Rick Scott remained deadlocked. Moscow denies meddling and Trump denies any collusion.
A record number of American voters are participating in one of the most divisive and crucial midterm elections in recent history, widely considered a referendum on President Trump's policies and fiery rhetoric.
Meanwhile, after denouncing her on the campaign trail for more than a month, Trump called House Democratic Leader Nancy Pelosi on Tuesday night (Wednesday NZT) to congratulate her for her party having retaken control of the House. A Republican-led Senate would allow Trump's conservative remaking of the US judiciary to continue.
Trump himself noted the energy as he wrapped up a punishing schedule of rallies around the country that were meant to boost Republican candidates - and his own brand heading towards reelection in 2020.
For Democrats, the road to the majority ran through the two dozen suburban districts Clinton won and through swaths of Trump country in the Rust Belt and heartland where voters backed the president two years ago.
Tuesday's elections also tested the strength of a Trump-era political realignment defined by evolving divisions among voters by race, gender, and especially education.
A loss of the House will also trigger significant second guessing of the President's tactics, given that he chose not to make the booming economy his primary midterm argument, instead turning to a searing indictment of Democrats focusing on immigration and laden with racial language.
Some of the campaign's biggest Democratic stars lost.
But also in Texas, Democratic Senate candidate Beto O'Rourke, a charismatic congressman and former punk rock singer who had raised an unprecedented $60 million in his mission to win in the Republican stronghold, fell short to arch-conservative former presidential contender Ted Cruz.
Incumbent Democratic Senator Joe Manchin won a hotly contested race in conservative West Virginia, and conservative Marsha Blackburn held a Senate seat for Republicans.
"We'll just have to work a little bit differently", he told reporters when asked how he'd live with a Democrat-controlled lower chamber. Democratic Senator Sherrod Brown was projected to hold his seat in Ohio.
The election saw all 435 seats in the House of Representatives and 35 of 100 in the Senate up for grabs, as well as 36 governorships, many of those state races toss-ups according to the polls.
"We will have a responsibility to find our common ground where we can, stand our ground where we can't", Pelosi said.
Voters cast their ballots in the midterm elections on November 6, 2018, in Appleton, Wisconsin. In the last such congressional elections in 2014, there were 27.5 million early votes.
At stake was control of at least one house in the United States Congress, and with it Trump's ability to drive ahead with an unconventional style of government that has divided Americans like rarely before. Most of those are Democrats trying to keep their seats.
The campaign unfolded against a backdrop of jarring political imagery, heated rhetoric and angry debates on immigration, health care and the role of Congress in overseeing the president.
Trump declared "the Republican agenda is the American dream" and at his final event, in Cape Girardeau, Missouri, he called on supporters to seize their "righteous destiny as Americans".
"This is the single most important off-year election of my lifetime". "I just couldn't believe it", he said, referring to Senate hearings were held where Kavanaugh was accused of sexually assaulting a woman when they were both teenagers. "I think it's about the character of the country", he said in Wilmington, Delaware, where he voted.