"One way or another, the way Mexico treats the undocumented immigrants from Central America affects Mexico's position in how it can criticize the USA government for its treatment of undocumented Mexican immigrants in the United States", Salazar told CNN en Español.
In a series of raging tweets, the U.S. president urged Mexico to "stop this onslaught" and prevent the would-be immigrants from entering the US. After an hour of rowdy yelling and chanting, some migrants managed to push open the fence and hundreds surged through behind them, overwhelming a small contingent of Guatemalan riot police officers.
Witnesses say some of the migrants threw rocks and other objects at Mexican security forces, who used pepper spray to force the migrants to retreat.
The U.S. -Mexico border between Tijuana and San Diego is the world's busiest land border crossing.
U.S. Secretary of State Mike Pompeo will travel to Mexico on Friday for a meeting with the country's top officials, where the caravan will likely be among the topics of discussion. Pompeo thanked Mexico for its efforts to address the migrant flow, including calling in the United Nations for assistance.
An immigration activist who led a similar migrant caravan through Mexico in April was arrested on Thursday in the Mexican city of Ciudad Hidalgo.
A large, USA -bound group of Central American migrants that President Donald Trump has been attacking all week reached Mexico's southern border Friday and started to cross over after a clash with law enforcement.
A group of migrants breached the Mexico-Guatemala border Friday, according to reports.
In a statement, the country's Institute of Migration (IGM) said: "Guatemala does not promote or endorse irregular migration in any forms, and therefore rejects movements organized for unlawful purposes which distort human rights, like migration, for their own end".
"It was predictable and also the election process is very close, so he is making a political calculation", he added.
It is unclear if they are trying to swim across to the Mexico side of border, go back to Guatemala or just get relief from the crowds on the bridge.
Mexico's government says migrants with proper documents can enter and those who don't either have to apply for refugee status or face deportation.
More Honduran migrants tried to join a caravan of several thousand trekking through Guatemala on Wednesday, defying calls by authorities not to make the journey. Those seeking asylum or some other form of protection can request it but must wait in a migration centre for up to 45 days, officials said, and those who try to enter illegally will be detained and deported.
Meanwhile in Arizona large groups of Central American migrants continue to surrender to Border Patrol agents, with the arrival of one recent group numbering 108 captured in dramatic video images, authorities said on Friday.