But winning at Ashe is as big as it gets.
Despite not being ranked as high as his contemporaries - Nadal and Federer in the lead up to the US Open, Djokovic was considered as the favourite, and boy, did he live up to the billing!
'I think that was one of the most important, so to say, moments and periods of my life, my tennis career, my development.
She lit up the past fortnight with her performances, not to mention a series of highly amusing interviews, and her future looks stunningly bright.
It came in a final which was business-like rather than thrilling, a relief for a tournament still reeling from the controversial women's final on Saturday.
"She seems nearly destined to succeed Williams as the world's highest-paid female athlete", Forbes said, estimating her off-court earnings may increase tenfold over the next couple of years, from $1.5 million to more than $15 million a year. "My heart was racing, like, the entire day", Osaka said.
Djokovic particularly struggles in the hot and humid conditions that hit NY over much of the fortnight and looked out of sorts against Marton Fucsovics in the first round - splitting the first two sets, he trailed 4-2 in the third - Joao Sousa in the fourth and giant killer John Millman in the quarterfinals. "Thank you", Osaka tweeted. Too (far) ahead of him with the Grand Slams.
It was her first. Osaka was also able to neutralize the Williams serve, widely regarded as one of the best in all of tennis, as she won 45% of return points.
Born in Japan to a Japanese mother and a Haitian father, Osaka was raised in the United States but competes for Japan. Now she's based in Florida.
It was revealed Williams has been fined £13,000 for the turn of events in the final, that saw her issued with three code violations.
Djokovic's second major title in a row, after Wimbledon in July, signaled fully that he is once again at the height of his powers.
"I had to kind of disconnect a little bit", said Djokovic. He claimed the last 16 sets he played.
The disappointment on Sunday belonged to a teary Del Potro who was back in a Grand Slam final for the first time since the big Argentine won his one and only title at Flushing Meadows in 2009. In the years between toppling Roger Federer in the 2009 final and Sunday's match, del Potro almost quit tennis after undergoing four wrist surgeries, three of them on his left wrist, that left him in a deep depression and had him seriously weighing retirement.
There was so much to talk about.
The U.S. Open final suddenly appeared to be slipping away from Novak Djokovic.
Some strong showings at the U.S. Open helped several men achieve career-best rankings, including Borna Coric to No. 18, Karen Khachanov to No. 25 and John Millman - who upset Federer - to No. 37.
Djokovic occasionally seemed annoyed by the support with the noise as British umpire Alison Hughes had to constantly plead with the crowd to remain quiet during points. The flap over the chair umpire who told Alize Cornet she couldn't change her shirt on court (allowed).
And now the world gets to watch the next phase of this and wonder: How many more majors can Federer, 37 and coming off a fourth-round exit at the U.S. Open, add to his total?