What is the team news? The venue of the match is at Old Trafford.
Pogba missed United training on Monday having picked up an injury in training last Friday, so his omission may have been linked to that. Ander Herrera is also still out, bu Marouane Fellaini will be in contention to start.
How have we been doing?
Manchester United need to win to advance.
But Mourinho insists it may be a while until the 29-year-old hits top form at Old Trafford.
"Normally top-teams have strong and quality players but I am not anxious about it".
Sevilla make one enforced change from the first leg as the injured Jesus Navas is replaced by Simon Kjaer.
Stay tuned here for live updates and highlights of goals and key plays from throughout the match (refresh for most recent updates).
However it's unsafe for the Red Devils as a Sevilla goal will leave them needing two so expect Jose Mourinho to shut up shop here.
How are Sevilla doing? . "If I finished the session one minutes before it wouldn't have happened".
Manchester Utd will take on Sevilla this evening.
What's our record like against Spanish opposition?
Jose Mourinho has said Manchester United fans may not see the best of Alexis Sanchez until next season.
Kick-off is at 7:45pm GMT and the game is being shown exclusively on BT Sport in the United Kingdom.
Mourinho won't allow himself to think of the quarter-finals just yet, however.
Most clubs would be delighted to be sitting second in the Premier League, into the FA Cup quarterfinals and on the verge of a return to the last eight of the Champions League.
"Loads of the UK's best sporting action, on the UK's fastest network".
Rivals Watch: Following the four ties that were played last week, there are four more last-16 games taking place this week.