Arsenal remaining confident and in control during the second half, but still conceded a fair few chances.
As a bonus, winning the continental competition assures the victor a spot in next year's UEFA Champions League and should the Gunners end their trophy drought on the continent, their long-suffering fans would indeed have something to cheer for. The only goal of the game was scored by Brazilian journeyman, Marcelo Guedes via an assist from former Manchester United winger, Memphis Depay to hand the former Ligue 1 champions a win and vital away going back to their home.
It was the result many Arsenal fans were fearing - a victory in Italy, the sort that will be used by Arsene Wenger and owner Stan Kroenke to once more paper over the yawning cracks at the Emirates.
They now sit in sixth place in the Premier League, and like Manchester United last season, may need to win the Europa as their way into Europe's top competition.
"We knew Milan was having a fantastic run so our main focus was to win the game".
"Those who play football know that it's hard to play this type of game". The Italians had gone 10 games without losing between these defeats.
Arsenal also looked to make early in-roads and, although some of their pass selections - short and easy - showed that confidence is lacking, one smart move ended with Mkhitaryan firing into the side-netting.
Ozil has been directly involved in 100 goals in 189 appearances for Arsenal - 37 goals and 63 assists.
In an Arsenal Supporters' Trust poll, 88 per cent voted for the 67-year-old to leave at the end of this season, despite his terms running until the end of 2018-19.