The forward's four goals see him move to 14 in his last seven appearances at the Etihad, and it's the first time he's scored in seven consecutive home games during his seven seasons at the club.
The Premier League leaders' boss Pep Guardiola has stated quite regularly that he believes his side receive more punishment than most from the opposition, and that referees must do more to protect, not only his, but all players of the game.
Reports had claimed Mahrez had made himself available for Leicester's match on Saturday, which ironically is against Manchester City, but at his press conference on Thursday manager Claude Puel said the Algerian would not be involved.
The Catalan coach's decision brought some stinging criticism, particularly from Sky pundit and former Manchester United captain Gary Neville, who believed Guardiola should have offered the chance of a matchday experience on the bench to one of City's many talented academy prospects.
Perhaps the playmaker thought his trio of assists cancelled out Aguero's four-goal haul, as he robbed his team-mate of the ball at the end of the game.
Just after an hour of play, Riyad Mahrez made his return to the Foxes side after a hard few weeks, with the winger coming off thew bench to applause from both sets of supporters.
Netting City's second in the 48th minute after Jamie Vardy had levelled proceedings, Sergio Aguero simply stole the show with three more second-half goals to kill off the game. Poor form from our closest competitors has left us still just one point from 7th, and four points clear of 9th, but the Foxes need to turn this around.
"There are 12 Premier League matches remaining. We've done it this way and we'll continue", he said.
Guardiola said Sane will not be fit for the Champions League Round of 16, first leg away to Basel on Tuesday but revealed the Germany winger was running again and hinted he could be back sooner than expected. "It is important to keep a good feeling together through these difficulties". "I think we will not often play a team good like this".