Midfielder Adam Lallana, who has not played since suffering a thigh injury in pre-season, is also back in full training and could also face his former club.
Southampton head to Anfield this Saturday for yet another installment of Premier League friends reunited. He had spells at Liverpool as both a player and a coach under Rafa Benitez and has good memories of his time on Merseyside. "I am 50 now so maybe I need to get used to it, but that's twice already in a British hospital now".
But when asked if life could be difficult for the Dutchman at Anfield, he replied: "Hopefully".
The 24-year-old stopper decided not to return to Huddersfield Town, where he helped The Terriers to promotion, on loan for this season but instead to stay and fight Simon Mignolet and Loris Karius for his place at Liverpool.
South Coast to North West has been a common trade route in recent years, with Liverpool's squad resembling something of a Southampton-on-Mersey after £98 million of spending on Saints since 2004.
A decision on Sadio Mane will be made nearer the time after he returned from Senegal duty with a slight hamstring problem.
Meanwhile, 13th-placed Southampton are without former Juventus man Mario Lemina on account of an ankle knock.
The German missed a home match against Sunderland in February 2016 as he had an emergency operation for appendicitis.
Sky Sports are showing the match live for Irish TV viewers on Sky Sports football with coverage starting at 2.55 pm.
Southampton have conceded defeat to Liverpool and will allow Virgil Van Dijk to move to Anfield if the Reds meet the Saints' £70million valuation, according to reports. "We have got a lot of good players and most of the teams want to sign them".