In Girona's first competitive meeting with Madrid, Machin's men claimed a stunning 2-1 win at home to the LaLiga titleholder on Sunday courtesy of a stirring second-half comeback.
Ronaldo and strike partner Karim Benzema huffed and puffed but could not find a way past a determined Girona side.
He also had a golden opportunity to equalise in the second half when Toni Kroos' free-kick found him in the 18-yard box, but his header was straight at the goalkeeper.
The altercation resulted in a five-match ban for the Portugal international, and was a sign of things to come for Madrid.
The fact that he'd be up against Marcelo and Isco didn't faze him as he continued to bomb down the right flank.
Before kick-off in Bilbao, the sad news arrived of the death of Manuel Sanchís Sr, a member of the 'ye-ye' Real team that won the European Cup in 1966. He was not present at the game but showed his delight at the result with a post on Twitter. True, and the rivals were quite serious.
After the game, there were some fantastic scenes as the jubilant Girona players drank in the atmosphere in the stadium and were given heartfelt congratulations by their manager as well as the club's board in the dressing room.
That is certainly the opinion of Madridistas who feel as though their chances of top-flight success are all but over.
Messi, on the other hand, has scored 12 in 10 games as Barcelona sit atop the league with 28 points.