Real made a profit of over 75 million euros ($90 million) in the transfer market thanks to the departures of Alvaro Morata, James Rodriguez and Danilo.
The Spanish giants became the first team in the Uefa Champions League era to win that trophy in successive seasons in June, seeing off Juventus 4-1 in the final in Cardiff.
Pochettino is under no illusions that Madrid will be nailed on favourites to top the group, but admits that APOEL could be right up there challenging for the runner-up spot. If not, they could be facing an uphill battle to get to the knockout rounds.
"You may think that we are lacking a "number nine", and maybe we are. There are so many factors".
Though he does not like to brag about it, Nacho has spent his whole career with Real Madrid, all 16 years of it -more than any other member of the current squad.
"They're banging on about unfair referees but no one from Real Madrid's mentioned that he pushed the referee".
Marco Asensio may be sidelined for the match against the Cypriot team.
Real barely missed him as they outclassed Manchester United to win the European Super Cup, although he came on as a late substitute in the 2-1 win.
"I have said before I want to break into that world-class bracket and to do that you have to play well in the Champions League", Kane said.
That's another reason for being glad to see Ronaldo's return.
Sports players are no strangers to weird injuries - sneezing too hard, ironing clothes, celebrating victories and playing too many video games have all kept players from competing at their best before.
Real had struggled for goals in their last two Liga encounters, surprise home draws with Valencia and Levante, and Ronaldo's return came at a flawless time for Zinedine Zidane's side, who were missing Karim Benzema and in-form forward Marco Asensio through injury. The Portuguese has been starved of football so far this season due to a long suspension.