Scroll through the gallery above to see the latest Champions League odds from Betfair. But one question looms above the rest: can anyone stop Real Madrid from winning the tournament for the third year in a row?
While Gareth Bale would undoubtedly move out of the shadow of Cristiano Ronaldo at Manchester United, Real Madrid is the best team in world football at the moment and the Welsh winger did well to stay at Los Blancos and fight for recognition and trophies this season. So who, if anyone, can challenge Europe's soccer powerhouse?
Manchester United which is making its 21 group stage appearance will be without Phil Jones and Eric Bailly who are serving a match ban.
However, they've started this season in rampant form and now have a very strong squad capable of competing on multiple fronts. Ed Woodward is also well known for his desire to sign Galactico-type players and did so in Pogba last season.
"Spurs host Real at their temporary home of Wembley at the start of November, and Bale said: "[White Hart Lane] is going to be a big miss for them, but with modern football I suppose other things are taken into consideration". And a look at their squad, and their stats, suggests there's little to stop them from extending their run.
Such is Real Madrid's confidence in creating more Champions League history that while others have spent hundreds of millions trying to catch up, the back-to-back European champions were happy to cash in. Brendan Rodgers' Celtic have gone from strength to strength since the turn of the year, and are unbeaten in their last 54 domestic matches.
"[Danny] Welbeck being back is also a big plus, but their problems are the same problems, and that central defensive area will be their Achilles heel this season". Have they got the players to win it?
Ahead of the return of UEFA Champions League action tonight, KickOff.com mulls over five things to look forward to in this season's European Cup. Real Madrid will release all their anger and frustration from their last few disappointing results on APOEL.
Off the pitch, we've expanded the stadium, gone full-time and then added the youth team, so a lot has gone on behind the scenes.
Neymar, at 25, and Antoine Griezmann (26) are the two most likely to deny Ronaldo and Messi the Ballon d'Or this season, but their ages deny them the chance to target a decade of dominance in the Champions League.
Against Levante, Real let so many chances go and now when the talk was that Real Madrid were able to cope without Ronaldo just fine, the goals dry up and the team and Zidane himself realised what they were missing.