It was a decision that sparked a huge debate on my Twitter feed and even with my Liverpool-tinted glasses on, you can see both sides of the argument.
Senegal global Mane, who will serve a three-match domestic ban after receiving a direct red, is likely to feature in the mid-week game while Brazilian playmaker Philippe Coutinho could make his first start of the campaign.
Mane was given a straight red card by referee Jon Moss for his challenge and, despite Liverpool fans and some pundits claiming that the tackle didn't merit a sending off, Ederson's facial injuries prove otherwise.
It was an accident, yet the laws of the game may suggest it was a red card.
The deadline-day signing from Arsenal of Alex Oxlade-Chamberlain - a player Klopp believes can become a Liverpool great - adds more firepower to an attack already boasting Sadio Mane and Roberto Firmino and which will soon be further boosted by the return from injury of Adam Lallana.
City's defence looked as woeful as Liverpool's in the first third of the match and they were let off the hook when Mane made his untimely exit.
As a result of the challenge, Ederson could not continue and he was stretchered off and replaced by Claudio Bravo.
Speaking to Sky Sports after the game, via Turkish Football, Carragher said: "Emre Can really struggled when he played in the middle of the back three and didn't look solid at all". We have seven games in the next three weeks so there will never be time really to train.
'But we didn't, and that's what the first half was like, we weren't compact enough and didn't cause them enough problems.
"It's so important for us to feel that we have one guy to help the central defenders". Mixed emotions that we managed to show heart and get back from 2-0 down and if we'd done that for the previous 37 we may not be facing the relegation. I wouldn't be surprised if that happens again on Saturday. The game is played two ways: one is played in possession and one is played out of it. And it quickly punctured the optimism gathering around their English Premier League title challenge following a 4-0 victory over Arsenal before the worldwide break.
But the Stoke City forward, a summer recruit from Schalke in Germany, did what no other player had done this season - he scored against Manchester United in the Premier League.
A number of City's players caught the eye but link-up play between strikers Aguero and Jesus was highly encouraging for boss Pep Guardiola.