Senegal worldwide Mane, who will serve a three-match domestic ban after receiving a direct red, is likely to feature in the mid-week game while Brazilian playmaker Philippe Coutinho could make his first start of the campaign.
Had a couple of early slip-ups but became more comfortable as the match went on and kept Roberto Firmino on a tight rein.
53' - GOAL! Manchester City 3-0 Liverpool (Jesus).
The Reds had started brightly but found themselves 1-0 down when Sergio Aguero opened the scoring and then a man down after Mane was given his marching orders having collided with Ederson trying to get on the end of a through ball.
After the game, Mendy endeared himself to the Manchester City support and the neutrals with some brilliant Tweets.
"You have to look forward but we still have to learn from this".
De Bruyne (R) was pulling the strings yet again! Movement created space and still had a hand in a goal.
However, the contact to Ederson's face was a worry, with the former Benfica man stretchered off the pitch and taken to hospital. After Mane's dismissal, which divided opinion among pundits, Gabriel Jesus and Leroy Sane each struck twice to wrap up the win.
The reshuffled back four was barely hanging on and the usually solid midfield trio was often guilty of either losing the ball or weak passes, which were intercepted by the more hungry City players.
GEORGINIO WIJNALDUM (replaced by Milner, 58): Struggled to get a grip in midfield with City dominating and eventually ran out of legs.
"All three up front were not really involved".
Manchester City goalkeeper Ederson has allayed concerns over his condition after being carried off during Saturday's match against Liverpool but he could still miss his team's Champions League opener.
That was City one up in the scoreline, and was nearly instantly enough to win the game, as it was very soon one up in players of men on the pitch. New signing Oxlade-Chamberlain was named on the bench.