United manager Jose Mourinho used a conservative 5-3-1-1 system against Real Madrid, but is likely to be bolder against West Ham, who have not won at Old Trafford in 10 years.
After losing Matic to rivals Manchester United and talisman Diego Costa unlikely to don the blue jersey again, Conte needs to reinvent last season's magic with the help of new recruits - Alvaro Morata and Tiémoué Bakayoko.
"Bakayoko is a good signing for us".
The Belgium global had earlier missed from just a few yards out with the goal gaping, but Mourinho was pleased with the way his £75m summer signing responded.
"He had a good fight against two good central defender and I am happy with this period and how he fits into - I am never exhausted to repeat - an awesome group".
"I mean he's been questioned about scoring in the big games, but that was a big problem for United a year ago, beating teams at home, teams they should beat, so I think he'll help with that". With Guardiola at the helm, Manchester City found out just how hard the rigours of life in the Premier League can be.
"I don't think we're going to see that replicated (in England)", said Premier League chairman Richard Scudamore.
But such was the maturity he showed during his first-team opportunities - notably in a 1-1 draw at Manchester United in January - that regular starter Nathaniel Clyne could soon be under pressure for his place.
Given the way the transfer market has behaved this summer, the Manchester United manager believes the club have done a great job in bringing in three of the four players he wanted.
He added: "They are very different".
The boss admitted he wants to improve the distribution of goals when he spoke to the media ahead of the Reds' opening league match against West Ham at Old Trafford on Sunday.
The 29-year-old Serbian was far from the most glamorous member of Chelsea's championship teams of 2015 and 2017, but he gave more talented players the freedom to cause havoc by doing the dirty work in midfield.
Most big transfers have dragged their feet this summer but this is one that could become clear very soon. We were playing a team full of fantastic players, we discussed the result until nearly the end.
In contrast, Arsenal fans in North London typically earn the most of all Premier League fans at £663 per week.